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Intracellular signalling in the oxidative stress response in eukaryotes
Reference
C08381
Principal Investigator / Supervisor
Professor Brian Morgan
Co-Investigators /
Co-Supervisors
Institution
Newcastle University
Department
School of Cell and Molecular Biosciences
Funding type
Research
Value (£)
167,739
Status
Completed
Type
Research Grant
Start date
20/04/1998
End date
20/04/2001
Duration
36 months
Abstract
A two component signal transduction transcription factor, Bry 1, regulates the oxidative stress response in Saccharomyces cerevisiae. However, the mechanism by which Bry1 is regulated is unknown though is likely to include upstream regulatory kinases and regulatory proteins that interact with a coiled-coil domain identified in the protein. Thus, the project will focus on the elaboration of the control of Bry 1 as an effector of signal transduction pathways which regulate the oxidative stress response. Using standard methods of biochemistry, molecular biology and genetics the specific aims are to investigate the role of phosphorylation and the coiled-coil domain in the regulation of Bry 1 by the oxidative stress response.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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