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Molecular and cellular basis of sensitivity regulation in nociceptive neurones
Reference
C08311
Principal Investigator / Supervisor
Professor Peter Anthony McNaughton
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Pharmacology
Funding type
Research
Value (£)
204,500
Status
Completed
Type
Research Grant
Start date
28/09/1998
End date
28/09/2001
Duration
36 months
Abstract
Nociceptors, or pain-sensitive neurones, are unlike other sensory receptors in that they exhibit increased sensitivity in response to prolonged noxious stimuli. Short-term sensitisation is mediated partly by activation of protein kinase C, while in the longer term receptor upregulation is thought to be important. The project will investigate which isoforms of PKC are responsible for sensitisation, and which isoforms are activated by a variety of sensitising agents. We shall also seek to establish whether upregulation of expression of bradykinin receptors contributes to long-term sensitisation, and which factors are responsible for receptor upregulation.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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