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Elucidation of the bacterial c-type cytochrome biogenesis pathway; redox protein assembly in the periplasm
Reference
C08007
Principal Investigator / Supervisor
Professor Stuart John Ferguson
Co-Investigators /
Co-Supervisors
Institution
University of Oxford
Department
Biochemistry
Funding type
Research
Value (£)
163,067
Status
Completed
Type
Research Grant
Start date
12/05/1997
End date
12/05/2000
Duration
36 months
Abstract
This laboratory has isolated a number of genes that are required for the biogenesis of the periplasmic c-type cytochromes that are vital for most modes of bacterial growth. We have also obtained biochemical insight into the roles of certain of these genes, some of which have counterparts of unknown function in eukaryotic cells. The proposed study will build on the experimental system we have established with Paracoccus denitrificans and include development of a number of new biochemical approaches which will elucidate the roles of the genes required for this biogenesis. It is anticipated that central questions concerning post-translational modifications in the periplasm will be answered.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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