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Non-phosphotyrosine mechanism of M-SCSF receptor degradation?
Reference
C07820
Principal Investigator / Supervisor
Dr Nicholas Dibb
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Dept of Medicine
Funding type
Research
Value (£)
139,759
Status
Completed
Type
Research Grant
Start date
01/09/1997
End date
31/08/2000
Duration
36 months
Abstract
The proto-oncogene c-fms encodes the receptor for the growth factor M-CSF (or CSF- 1). The binding of M-CSF activates receptor signalling and receptor degradation, both of these processes are held to be dependent upon autophosphorylation of key tyrosine residues within the intracellular domain of the receptor. We have isolated a mutant M-CSF receptor that is degraded independently of kinase activity. Here, it is proposed to test and establish the hypothesis that normal M-CSF-induced receptor degradation is at heart mediated by a non-phosphotyrosine mechanism, which it is proposed to characterise.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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