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Assembly of cytochrome c-dependent electron transfer chains in bacteria: are there chaperones in the periplasm?
Reference
C07661
Principal Investigator / Supervisor
Professor Jeffrey Cole
Co-Investigators /
Co-Supervisors
Institution
University of Birmingham
Department
Sch of Geography, Earth & Env Sciences
Funding type
Research
Value (£)
149,873
Status
Completed
Type
Research Grant
Start date
01/09/1997
End date
01/09/2000
Duration
36 months
Abstract
Three anaerobically induced electron transfer chains of enteric bacteria include c-type cytochromes. Their operons are unexpectedly complex, encoding the terminal reductases, other electron transfer proteins, assembly and folding functions. The aims are to determine how c-type cytochromes are assembled in the periplasm of Escherichia coli; the roles of individual cytochrome c maturation proteins and how they interact with disulphide bond formation proteins acting like chaperones in the ordered assembly of multi-haem c-type cytochromes; factors that increase the rate of turnover of the electron transfer components; whether there are two haem transporters (for cytochrome oxidase Cyd and another for haem c) and two haem lyases, one to catalyse attachment of haem to a novel C-W-S-C-K motif of cytochrome c552.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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