BBSRC Portfolio Analyser
Award details
Constitutive activation of D2 dopamine receptors and the mechanism of inverse agonism
Reference
C06913
Principal Investigator / Supervisor
Professor Philip Gordon Strange
Co-Investigators /
Co-Supervisors
Institution
University of Reading
Department
Animal and Microbial Sciences
Funding type
Research
Value (£)
119,232
Status
Completed
Type
Research Grant
Start date
07/01/1997
End date
07/01/2000
Duration
36 months
Abstract
Coupling of D2 dopamine receptors to G-proteins in the absence of agonist stimulation (constitutive activation) and reversal of this constitutive activation by inverse agonists will be investigated in recombinant CHO cells expressing D2 receptors. Parameters affecting constitutive activation and inverse agonism will be examined including the effect of different levels of receptor expression, and structural requirements in the ligand and in the receptor. The mechanism of inverse agonism and the effect of stimulation, short and long term with inverse agonist, on receptor levels will be examined. Inverse agonism in native tissues expressing D2 receptors will be probed. Overall the results will provide exciting new information on receptor function.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search