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SRP-independent protein targeting to the ER in yeast
Reference
C06887
Principal Investigator / Supervisor
Professor Colin Stirling
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
185,087
Status
Completed
Type
Research Grant
Start date
01/10/1996
End date
31/12/1999
Duration
39 months
Abstract
The aim of this study is to identify and characterise components of a novel SRP-independent pathway for the targeting of proteins to the ER in yeast. Using a genetic approach in S. cerevisiae we have identified a number of mutants that are defective in this pathway. These mutants will be exploited in three major ways. Firstly, their phenotypic analysis will reveal the relative importance of this targeting pathway in vivo. Secondly, they will facilitate the cloning and characterisation of those genes involved in this phenomenon. Finally, the mutants themselves will facilitate the biochemical dissection of the pathway enabling us to resolve the precise role that each component plays in what is clearly a complex process.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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