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Role of the CRE/CREB factor in cyclic AMP and NGF signalling in neuronal cells
Reference
C06736
Principal Investigator / Supervisor
Professor David Latchman
Co-Investigators /
Co-Supervisors
Institution
University College London
Department
Immunology and Molecular Pathology
Funding type
Research
Value (£)
152,842
Status
Completed
Type
Research Grant
Start date
14/04/1997
End date
31/12/2000
Duration
44 months
Abstract
The AMP response element (CRE) in the CGRP gene promoter is necessary but not sufficient for activation by NGF but is necessary and sufficient for activation by cAMP. Both stimuli result in phosphorylation of the CREB transcription factor on serine 133 which is required for stimulation of transcription. To determine the basis for the difference in these two signalling pathways we will compare their ability to cause CREB phosphorylation at other potential regulatory sites and test their effects on transcriptional activity of intact CREB or specific sub-domains of the protein and upon the ability of CREB to associate with the CBP co-activator.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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