Award details

The terminal steps of chlorophyll biosynthesis

Reference	C06590
Principal Investigator / Supervisor	Krebs Professor of B Christopher Hunter
Co-Investigators / Co-Supervisors
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	135,021
Status	Completed
Type	Research Grant
Start date	01/12/1996
End date	01/12/1999
Duration	36 months

Abstract

The aim of the project is to study the enzymes that catalyse the terminal steps of chlorophyll (chl) biosynthesis. The enzymes that catalyse these reactions, which are responsible for the attachment of geranylgeraniol (GG) and the reduction of this moiety to phytol, are encoded by bchG and P from Rhodobacter sphaeroides and chlG and P from the cyanobacterium Synechocystis; they will be overexpressed in E. coli and the cognate proteins will be purified. A detailed characterisation of these enzymes will include substrate specificity and the interactions between the proteins. The second part of this project will study the properties of the novel LH and RC complexes produced by bchP mutants, which contain bchl-GG instead of bchl-phytol.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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