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A molecular analysis of membrane protein insertion at the endoplasmic reticulum
Reference
C06156
Principal Investigator / Supervisor
Professor Stephen High
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
163,061
Status
Completed
Type
Research Grant
Start date
01/06/1996
End date
01/06/1999
Duration
36 months
Abstract
The endoplasmic reticulum (ER) is a major site of membrane protein biosynthesis in eukaryotic cells. The aim of this project is to understand the molecular events which mediate the insertion of single-spanning proteins into the ER membrane. Site-specific cross-linking techniques will be used to dissect interactions between distinct regions of membrane proteins and components of the ER insertion site. A range of translocation intermediates will be used in order to study these interactions at different stages of the biosynthetic process. The mechanism by which transmembrane domains can laterally exit the ER insertion site, allowing the stable integration of proteins into the lipid bilayer, will be investigated.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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