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The cofactor-like activity of phosphatidylinositol transfer protein in inositol lipid mediated cell signalling

Reference	C06011
Principal Investigator / Supervisor	Professor Geraint Thomas
Co-Investigators / Co-Supervisors	Professor C Ganellin
Institution	University College London
Department	Physiology
Funding type	Research
Value (£)	99,768
Status	Completed
Type	Research Grant
Start date	05/08/1996
End date	05/08/1998
Duration	24 months

Abstract

Phosphatidylinositol transfer protein (PITP), supports efficient signalling through inositol lipid hydrolysis but its mechanism of action is not understood. Current hypotheses depict PITP as a soluble vector or chaperone for signalling-dedicated inositol lipids, and predict the in situ polyphosphorylation of phosphatidylinositol and the hydrolysis of the products. We will test the predictions by covalently linking phosphatidylinositol to PITP to produce a unique set of probes that will report this in situ metabolism and thereby directly test the hypothesis. We anticipate that if this cofactor or vector model can be substantiated it will provide an impetus for future drug design.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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