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Role of the NSF-related VCP in endosomal vesicle fusion and its regulation during the cell cycle
Reference
C05969
Principal Investigator / Supervisor
Professor Philip Woodman
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Medical and Human Sciences
Funding type
Research
Value (£)
139,798
Status
Completed
Type
Research Grant
Start date
07/11/1996
End date
07/11/1999
Duration
36 months
Abstract
Endosomal vesicle fusion is supported by the ubiquitous fusion protein NSF (NEM Sensitive Factor), an ATPase containing 2 ATP binding domains. We have preliminary evidence that endosomal vesicle fusion is also supported by the NSF-related VCP (Valosin Containing Protein), an abundant protein with an as-yet unknown activity. We intend to extend our investigations to confirm the involvement of VCP. VCP is distinguished from NSF by the presence of a consensus site for phosphorylation by the mitotic kinase cdc2. Since this site is adjacent to an ATP binding site, we intend to examine the phosphorylation of VCP in vivo and in vitro, and to assay the effect of such phosphorylation on the ATPase and transport activities of VCP.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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