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The role of CD45 in regulating the molecular events of early thymocyte development
Reference
C05886
Principal Investigator / Supervisor
Dr Nicholas Holmes
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Pathology
Funding type
Research
Value (£)
163,606
Status
Completed
Type
Research Grant
Start date
01/11/1996
End date
30/10/2000
Duration
48 months
Abstract
The aim of this project is to investigate the role of CD45 in regulating the molecular events which control the development of CD4-CD8- into CD4+CD8+ thymocytes, with a particular focus on pre-TCR signalling and p56lck. The project will be carried out using CD45-/- transgenic mice in which there is a partial block at this stage of development, and in transgenic mice expressing only the CD45RO isoform or the CD45 cytoplasmic tail. Studies will be carried out using foetal thymus organ cultures and purified CD4-CD8- thymocytes and will involve a detailed molecular analysis of the signalling events which mediate this key step in thymic development. The results will elucidate a vital though poorly understood stage in the development of the immune system.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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