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Award details
Biochemical studies of native and recombinant N-methyl-D-aspartate receptors of vertebrate brain
Reference
C05749
Principal Investigator / Supervisor
Professor Frances Stephenson
Co-Investigators /
Co-Supervisors
Institution
University College London
Department
Dept of Pharmaceutical and Biological Ch
Funding type
Research
Value (£)
146,217
Status
Completed
Type
Research Grant
Start date
01/10/1996
End date
01/10/1999
Duration
36 months
Abstract
This proposal aims to determine the subunit complements, subunit ratios and properties of native N-methyl-D-aspartate receptors expressed in adult mammalian brain. Novel sequence-directed antibodies will be raised and used for the quantitative immunoaffinity purification and characterisation of NMDA receptor subpopulations. In parallel, the properties of cloned receptor subtypes with defined subunit complements will be studied focusing particularly on the splice forms of NR1.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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