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The role of mitogen-stimulated HMG-14 phosphorylation in immediate-early gene induction
Reference
C05232
Principal Investigator / Supervisor
Professor Louis Mahadevan
Co-Investigators /
Co-Supervisors
Professor Austin Smith
Institution
King's College London
Department
Reproductive Health Endocrinology Dev
Funding type
Research
Value (£)
137,820
Status
Completed
Type
Research Grant
Start date
01/01/1996
End date
30/03/1999
Duration
39 months
Abstract
Growth factors control cell division differentiation and apoptosis by rapidly re- programming transcription in the nucleus. Our recent work suggests involvement of two nucleosomal proteins, histone H3 and HMG-14, in this process (Cell, 1991, 65, 775-783; PNAS USA; 1994, 91, 4781-4785; EMBO Journal, 1994, 13, 4524-4535). Concomitant with immediate early (IE) gene induction, HMG-14 is rapidly phosphorylated on serine 6 adjacent to its nucleosome-binding region. Further, we have shown mitogen-regulated HMG-14 kinase in vitro in nucleosomes isolated from stimulated cells. We propose here to investigate the significance of mitogen-stimulated HMG-14 phosphorylation to IE gene induction by a combination of gene-targeting, ser6 mutation, and over-expression studies.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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