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Natural resistance-associated macrophage protein (Nramp): functional effects of PKC-mediated phosphorylation and protein interactions
Reference
C05216
Principal Investigator / Supervisor
Dr Charles Howard Barton
Co-Investigators /
Co-Supervisors
Institution
University of Southampton
Department
Centre for Biological Sciences
Funding type
Research
Value (£)
151,548
Status
Completed
Type
Research Grant
Start date
01/01/1996
End date
01/01/1999
Duration
36 months
Abstract
Genetic susceptibility factors have been the focus of research in diseases caused by infection, autoimmunity and cancer. The natural resistance-associated macrophage protein (Nramp), recently cloned as a susceptibility factor for infectious disease, regulates macrophage effector functions for microbicidal activity. The complete amino acid sequence encodes a hydrophobic protein with similarity to two yeast mitochondrial transporters. Two domains of Nramp are of significant interest; the proline serine rich amino terminus which includes three consensus sites for protein kinase C-mediated phosphorylation and the conserved transport motif. A combination of molecular, cellular and biochemical techniques involving the yeast two hybrid system, macrophage transfection of in vitro mutated constructs and protein sequencing will be used to study Nramp function.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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