BBSRC Portfolio Analyser
Award details
Molecular studies on a novel signal transduction pathway regulating FcgammaRi-mediated internalisation of immune complexes
Reference
C05002
Principal Investigator / Supervisor
Professor Janet Allen
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
IBLS Division of Biochemistry & Molecula
Funding type
Research
Value (£)
174,918
Status
Completed
Type
Research Grant
Start date
01/01/1996
End date
31/07/1999
Duration
43 months
Abstract
Receptors (FcgammaRI) recognising the constant region of immunoglobulins play a pivotal role linking the humoral and cellular arms of the immune system. Aggregation of Fcgamma receptors on macrophages causes these cells to undergo a repertoire of responses that amplifies and targets the immune system to invading pathogens and can lead to cell killing. FcgammaRI is unique among these receptors as it binds monomeric IgG at physiological concentrations. As such, presumably to prevent accidental macrophage activation by Fcgamma RI, endocytosis of immune complexes is very tightly regulated and involves a number of novel, regulated steps. In this proposal, we will define the nature of the novel pathways identified from these preliminary studies.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search