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Physiological consequences of lactate production during anoxia in plants
Reference
C04239
Principal Investigator / Supervisor
Dr Nicholas Kruger
Co-Investigators /
Co-Supervisors
Professor Richard Ratcliffe
Institution
University of Oxford
Department
Plant Sciences
Funding type
Research
Value (£)
158,136
Status
Completed
Type
Research Grant
Start date
01/10/1994
End date
01/10/1997
Duration
36 months
Abstract
The aim of this work is to establish the role of lactate production during anaerobic metabolism in plants. Potato will be transformed with chimeric genes containing appropriate regions of lactate dehydrogenase in the antisense orientation. Transgenic plants deficient in lactate dehydrogenase will be used to determine the extent to which lactate accumulation contributes to the fall in cytoplasmic pH at the onset of anoxia. These plants will also be used to study the consequences of lactate synthesis on carbohydrate metabolism under anoxia. Metabolic control analysis will be used to quantify the contribution of lactate dehydrogenase to the regulation of lactate production and other metabolic processes.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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