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Requirements for the membrane translocation of ricin A chain into the cytosol of mammalian cells
Reference
C04236
Principal Investigator / Supervisor
Professor Michael Lord
Co-Investigators /
Co-Supervisors
Professor Lynne Roberts
Institution
University of Warwick
Department
Biological Sciences
Funding type
Research
Value (£)
124,110
Status
Completed
Type
Research Grant
Start date
09/12/1994
End date
12/02/1998
Duration
38 months
Abstract
(1) To determine whether the A chain of ricin by itself carries all the information permitting membrane translocation; (2) to delineate a translocation domain in ricin A chain and to identify key residues involved in the membrane traversal event; (3) to determine whether there is a requirement for proteolytic processing prior to membrane translocation.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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