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Transport signals and pathways for membrane spanning proteins in the plant endomembrane system
Reference
C04082
Principal Investigator / Supervisor
Dr Jurgen Denecke
Co-Investigators /
Co-Supervisors
Institution
University of York
Department
Biology
Funding type
Research
Value (£)
142,578
Status
Completed
Type
Research Grant
Start date
01/09/1995
End date
01/09/1998
Duration
36 months
Abstract
Proteins synthesised on the endoplasmic reticulum (ER) membrane are folded, packed into vesicles and transported towards the Golgi apparatus, which serves as a junction from which several vesicle transport routes diverge. These lead to the vacuoles, the plasma membrane and back to the ER. We want to study plant cells and compare the general transport pathways for soluble (lumenal) proteins with those of membrane spanning proteins. Our first aim is to determine which is the default location for membrane proteins. Secondly, we want to study sorting signals responsible for retrograde Golgi to ER transports and thus accumulation of proteins in the membranes of the ER and the nuclear envelope. Finally, we want to analyse the complexity of transport pathways between the ER and the Golgi for the three different types of proteins.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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