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Structure and function of Ins(1,3,4,5)P4 binding proteins in platelets
Reference
C04063
Principal Investigator / Supervisor
Professor Alan Dawson
Co-Investigators /
Co-Supervisors
Institution
University of East Anglia
Department
Biological Sciences
Funding type
Research
Value (£)
128,994
Status
Completed
Type
Research Grant
Start date
03/07/1995
End date
03/07/1998
Duration
36 months
Abstract
We have purified a putative Ins(1,3,4,5)P4 receptor (p104) from platelets, and obtained partial sequence data as a prelude to cloning and sequencing. We are in the process of raising and characterising antibodies to this protein. However, in the process of purification and during experiments with an InsP4 affinity probe, we have detected and partially characterised other InsP4-binding proteins some of which are possibly PtdIns(3,4,5)P3 receptors. We require another position on our current Link Grant to clone and sequence p104, so enabling us also to explore the biological function and molecular biology of these other InsP4- binding proteins.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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