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Structure-activity relationships of D-glucuronide and L-fucose membrane transport proteins
Reference
C04061
Principal Investigator / Supervisor
Professor Peter Henderson
Co-Investigators /
Co-Supervisors
Professor Andreas Kurt Hans Holzenburg
Institution
University of Leeds
Department
Inst of Molecular & Cellular Biology
Funding type
Research
Value (£)
149,347
Status
Completed
Type
Research Grant
Start date
25/09/1995
End date
25/09/1998
Duration
36 months
Abstract
The aim is to elucidate the 3D structure and molecular mechanisms of the important membrane proteins for transport of glucuronide-(H+, Na+) and L-fucose-H+ found in bacteria. Specific questions are: which parts of the proteins recognise sugar and/or cation; which parts contribute to trans-membrane sugar-cation movement; is the 12-helix model of the protein structure true? The principal techniques are 2D and 3D crystallisation trials on each protein, and electron or X-ray diffraction. The mechanism will be studied by protein engineering, allied to biochemical, genetical, immunochemical, and biophysical methods.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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