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Purification and molecular characterisation of NEM-sensitive phosphatidic acid phosphatase (PAP1)
Reference
C04060
Principal Investigator / Supervisor
Professor Steve Yeaman
Co-Investigators /
Co-Supervisors
Professor Christopher Day
Institution
Newcastle University
Department
School of Cell and Molecular Biosciences
Funding type
Research
Value (£)
147,333
Status
Completed
Type
Research Grant
Start date
01/10/1995
End date
01/10/1998
Duration
36 months
Abstract
Phosphatic acid phosphatase (PAP) plays a key role in lipid metabolism and cell signalling. We propose to (1) purify the PAP1 isozyme to homogeneity; (2) study its molecular properties, particularly its substrate specificity; (3) clone and sequence cDNA encoding the polypeptide(s); (4) study molecular basis of its acute and chronic regulation by hormones and other effectors.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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