Award details

Reconstitution of nerve terminal derived clathrin coated vesicle fusion

Reference	C03602
Principal Investigator / Supervisor	Professor Michael Clague
Co-Investigators / Co-Supervisors
Institution	University of Liverpool
Department	Physiology
Funding type	Research
Value (£)	76,086
Status	Completed
Type	Research Grant
Start date	15/10/1995
End date	15/10/1997
Duration	24 months

Abstract

The purpose of this proposed research project is to establish a protocol whereby clathrin coated vesicles derived from the nerve terminal of bovine brains can be detergent solubilised and reconstituted into membrane vesicles, such that these vesicles possess a capacity to undergo fusion with a physiologically relevant membrane preparation. This would represent a breakthrough in the field of intracellular fusion. It would allow experimental manipulation of the protein and lipid composition of the fusing membranes and allow direct testing of the role of candidate fusion proteins.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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