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Microtubule dynamics in living plant cells

Reference	C02324
Principal Investigator / Supervisor	Dr R Warn
Co-Investigators / Co-Supervisors
Institution	University of East Anglia
Department	Biological Sciences
Funding type	Research
Value (£)	112,744
Status	Completed
Type	Research Grant
Start date	23/01/1995
End date	22/05/1998
Duration	40 months

Abstract

In linked research grant LR 83/550 we proposed to study microtubule dynamics in living plant cells. By microinjecting fluorescent pig brain tubulin we have now established by confocal laser scanning microscopy that microtubules display highly dynamic properties in tissue cells. For the first time we have seen microtubules directly as they reorientate through 90 degrees (Yuan et al 1994. PNAS In press), in a manner completely unexpected from fixation studies, calling for a reassessment of previous data. We predict that the broad range of agents which shift the direction of cell expansion are likely to do so via common effects on MT dynamics, offering a unifying level of study to this area of plant physiology. We will investigate how plant growth regulators and cold modulate the dynamic instability of MTs, their alignment and the direction of cell expansion. To begin examining the signalling chain we will investigate whether effects on MT dynamics are mediated by ions, cytoplasmic pH and microtubule-associated proteins.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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