BBSRC Portfolio Analyser
Award details
The role of CD45 in signalling pathways mediated by GP1-linked molecules in T-cells.
Reference
C02308
Principal Investigator / Supervisor
Professor Geoff Hale
Co-Investigators /
Co-Supervisors
Dr Nicholas Holmes
Institution
University of Cambridge
Department
Pathology
Funding type
Research
Value (£)
153,439
Status
Completed
Type
Research Grant
Start date
01/11/1994
End date
01/01/1998
Duration
38 months
Abstract
The main objective of this proposal is to facilitate the use and development of mAbs against GP1-linked molecules as pharmaceutical reagents by elucidating the mechanisms whereby they regulate T-cell function, with particular reference to the role of CD45. The signalling properties of mAbs against GP1-linked molecules will be investigated in CD45- and CD45+ T cell-lines, purified primary CD45RA+ and CD45RO+ T-lymphocyte sub-sets and T-cells derived from CD45-deficient transgenic mice. The project will elucidate the role of CD45- activated tyrosine kinases in the transduction of signals via GP1-linked molecules, the specific functions of CD45 isoforms and the possible role of CD45 as a 'coupling molecule' between GP1-molecules and the cell interior.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search