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Analysis of the redox components, role and biosynthesis of the periplasmic nitrate reductase system of Paracoccus denitrificans

Reference	C02012
Principal Investigator / Supervisor	Professor David Richardson
Co-Investigators / Co-Supervisors	Professor Stuart John Ferguson
Institution	University of East Anglia
Department	Biological Sciences
Funding type	Research
Value (£)	134,201
Status	Completed
Type	Research Grant
Start date	01/01/1995
End date	01/01/1998
Duration	36 months

Abstract

This project derives from our recent success in cloning the genes for the periplasmic nitrate reductase of the denitrifying bacterium P. denitrificans LMD81.2 and biochemically characterising the enzyme. The aims are (i) to investigate the structure and function of a tetra-haem c-type cytochrome that is identified by an open reading frame adjacent to the structural genes of the periplasmic enzyme; (ii) to probe the functions of low potential redox centres associated with the enzyme; (iii) study a protein segment of the enzyme that is predicted to have a key role in catalysis and (iv) initiate an investigation of how the molybdenum cofactor is acquired by the periplasmic enzyme.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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