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Mechanisms of mitogenic signal transduction by wild type and mutant G-protein-linked serpentine receptors

Reference	C01583
Principal Investigator / Supervisor	Professor Graeme Milligan
Co-Investigators / Co-Supervisors	Dr Neil Anderson
Institution	University of Glasgow
Department	IBLS Division of Biochemistry & Molecula
Funding type	Research
Value (£)	152,002
Status	Completed
Type	Research Grant
Start date	20/10/1994
End date	20/10/1997
Duration	36 months

Abstract

Rat 1 fibroblasts will be transfected to express varying levels of molecularly defined wild type and mutant Gi-linked alpha2 adrenoceptors. These clones will provide model systems to delineate the mechanisms linking agonist occupation of such receptors to downstream mitogenic pathways. The nature of the G-protein(s) activated by the receptors, their regulation of second messenger production and phosphorylation and activation of MAP kinase isoforms and other kinases involved in mitogenic cascades will be examined. These studies will provide valuable and novel information relevant to all systems in which growth factors, whose receptors do not possess intrinsic tyrosyl kinase activity, regulate cell division.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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