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The P-glycoprotein-associated epithelial chloride channel
Reference
C01408
Principal Investigator / Supervisor
Professor Christopher Higgins
Co-Investigators /
Co-Supervisors
Institution
University of Oxford
Department
Dyson Perrins Laboratory
Funding type
Research
Value (£)
231,677
Status
Completed
Type
Research Grant
Start date
01/04/1994
End date
31/05/1997
Duration
37 months
Abstract
P-glycoprotein is a unique protein, associated with both active transport and volume-regulated chloride channel activities. These two functions are separable and appear to represent alternate functional configurations of the protein. The aims of this proposal are threefold:to investigate the mechanism of interconversion between the transporter and channel configurations, particularly the role of protein kinase C; to elucidate the physiological role(s) of the P-glycoprotein associated chloride channel in epithelial physiology (particularly of the gut); to study the functional relationship between the P-glycoprotein channel and the closely related epithelial chloride channel protein CFTR (the product of the cystic fibrosis gene).
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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