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Signalling in mature and immature B-lymphocytes
Reference
C01360
Principal Investigator / Supervisor
Professor Margaret Harnett
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
Immunology & Bacteriology
Funding type
Research
Value (£)
136,631
Status
Completed
Type
Research Grant
Start date
01/04/1994
End date
01/10/1997
Duration
42 months
Abstract
The mechanism by which the antigen receptors elicit functional tolerance or activation is one of the central problems in B cell differentiation yet to be resolved. This programme will identify antigen receptor-coupled signals which contribute to the differential responses of tolerance and activation observed in immature and mature B cells. In particular, we shall (i) define the role of protein kinase C activation in signalling leading to tolerance or proliferation; (ii) characterise the involvement of protein kinase C isoforms in the transduction of positive or negative signals and (iii) identify additional sources of antigen receptor-mediated diacylglycerol generation required for prolonged protein kinase C activation and cellular proliferation.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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