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Membrane biogenesis and post meiotic gene expression in the generation of sperm structural heterogeneity
Reference
C01353
Principal Investigator / Supervisor
Dr Alison Moore
Co-Investigators /
Co-Supervisors
Professor William Vincent Holt
Institution
Institute of Zoology
Department
Institute of Zoology
Funding type
Research
Value (£)
206,642
Status
Completed
Type
Research Grant
Start date
01/04/1994
End date
30/11/1997
Duration
44 months
Abstract
The aim of the project is to elucidate pathways of membrane and organelle biogenesis in the mammalian testis. An integrated ultrastructural and molecular biological approach will be used to investigate sperm assembly mechanisms. Using specific antibodies and corresponding cDNA probes we will trace gene transcription and translation in spermatocytes and spermatids. Particular attention will be paid to post meiotic events. Intracellular trafficking and targeting signals of synthesized proteins will be investigated. The project will provide insights into sperm structural and functional heterogeneity within ejaculates.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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