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Award details
Unique properties of chloroplast and bacterial chaperonins: X-ray, EM and biochemical studies
Reference
C01287
Principal Investigator / Supervisor
Professor R Ellis
Co-Investigators /
Co-Supervisors
Professor Helen Saibil
,
Dr Stephen Wood
Institution
University of Warwick
Department
Biological Sciences
Funding type
Research
Value (£)
132,282
Status
Completed
Type
Research Grant
Start date
24/05/1994
End date
24/05/1997
Duration
36 months
Abstract
The scientific aim of this proposal is to understand the structure and function of the chloroplast and bacterial chaperonins in assisting protein folding. We wish to capitalise on recent progress made in the joint interdisciplinary programme of work between the Dept of Crystallography, Birkbeck College, and the Dept of Biological Sciences, Warwick University, on the X-ray and EM analyses of the bacterial chaperonins. We wish to expand these studies, and to extend them with new biochemical approaches, with particular emphasis on the chloroplast chaperonins, which possess several unique features; these include the occurrence of two different 60 kDa subunits, a novel double-headed form of chaperonin 10, and a reversible ALP-induced dissociation of chaperonin 60. (Joint with grant C01286).
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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