Award details

A functional genomic approach to understanding the molecular pathogenesis of sheep scrapie

Reference	BS516875
Principal Investigator / Supervisor	Professor John Hopkins
Co-Investigators / Co-Supervisors	Professor John Fazakerley, Dr Anton Gossner, Professor Nora Hunter
Institution	University of Edinburgh
Department	Veterinary Biomedical Sciences
Funding type	Research
Value (£)	896,852
Status	Completed
Type	Research Grant
Start date	01/03/2002
End date	31/08/2008
Duration	78 months

Abstract

This project will test the hypothesis that: 1). there are changes in relative levels of gene transcripts occurring in the CNS and FDC at specific times after scrapie infection in sheep; 2). TSE-induced changes to host cell gene expression are related to the clinical manifestation of scrapie disease; 3). the differential susceptibility of the distinct genotypes to scrapie-induced disease is related to differential gene expression in the CNS and FDC. These hypotheses will be tested by microarray technology using a non-redundant bovine brain EST library augmented by genes from a sheep FDC cDNA library, from TSE infected animals. We will identify and quantify changes in CNS and FDC gene expression related to scrapie disease progression, in homozygous sensitive VRQ/VRQ, heterozygous VRQ/ARQ, and homozygous resistant ARR/ARR New Zealand Cheviot sheep.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	Animal Health, Neuroscience and Behaviour, TSEs (transmissible spongiform encephalopathies)
Research Priority	X – Research Priority information not available
Research Initiative	Biology of Spongiform Encephalopathies - Phase 5 (BS5) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

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