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Physiological roles of prion protein
Reference
BS516776
Principal Investigator / Supervisor
Professor John Jefferys
Co-Investigators /
Co-Supervisors
Professor John Collinge
Institution
University of Birmingham
Department
Medical Sciences - Physiology
Funding type
Research
Value (£)
245,520
Status
Completed
Type
Research Grant
Start date
01/04/2003
End date
01/04/2006
Duration
36 months
Abstract
We identified a physiological phenotype in mice with a knockout of prion protein (PrP). The slow afterhyperpolarisation (AHP) was markedly reduced in hippocampal pyramidal neurons. This AHP is due to potassium current activated by intracellular calcium. We plan to : 1). test whether the AHP change reflects changes in potassium conductance, and of altered calcium homeostasis; 2). test whether the phenotype is related to free radical scavenging and/or Cu2+ homeostasis; and 3). explore the functional consequences of deleting the N-terminal region of PrP.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Biology of Spongiform Encephalopathies - Phase 5 (BS5) [2001]
Funding Scheme
X – not Funded via a specific Funding Scheme
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