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Physiological roles of prion protein

ReferenceBS516776
Principal Investigator / Supervisor Professor John Jefferys
Co-Investigators /
Co-Supervisors
Professor John Collinge
Institution University of Birmingham
DepartmentMedical Sciences - Physiology
Funding typeResearch
Value (£) 245,520
StatusCompleted
TypeResearch Grant
Start date 01/04/2003
End date 01/04/2006
Duration36 months

Abstract

We identified a physiological phenotype in mice with a knockout of prion protein (PrP). The slow afterhyperpolarisation (AHP) was markedly reduced in hippocampal pyramidal neurons. This AHP is due to potassium current activated by intracellular calcium. We plan to : 1). test whether the AHP change reflects changes in potassium conductance, and of altered calcium homeostasis; 2). test whether the phenotype is related to free radical scavenging and/or Cu2+ homeostasis; and 3). explore the functional consequences of deleting the N-terminal region of PrP.

Summary

unavailable
Committee Closed Committee - Agri-food (AF)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative Biology of Spongiform Encephalopathies - Phase 5 (BS5) [2001]
Funding SchemeX – not Funded via a specific Funding Scheme
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