Award details

How prion infection is taken up by intestine and nerve

Reference	BS516350
Principal Investigator / Supervisor	Professor Roger James Morris
Co-Investigators / Co-Supervisors	Professor Helen Cox, Professor Susan Hall
Institution	King's College London
Department	GKT School of Medicine
Funding type	Research
Value (£)	483,976
Status	Completed
Type	Research Grant
Start date	12/08/2002
End date	11/01/2006
Duration	41 months

Abstract

Major barriers to the spread of ingested prion infection occur, initially at the mucosal epithelial barrier in the gut, and subsequently in the transfer of infection to nerve. Knowing the detailed cellular interactions that promote, and prevent, the spread of infection at these critical stages will provide a rational basis for therapeutic intervention. We will apply complementary in vivo and ex vivo approaches to identify the cellular interactions involved in the spread of infectious prion agent across the mucosal epithelial layer of the small intestine and along peripheral nerves to the central nervous system. Specifically, we will investigate i). whether the intestine responds to the presence of infectious agent; ii). the cellular route(s) used to transport infection across the mucosal epithelia; and iii). how infection is taken up and transported along nerves.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Biology of Spongiform Encephalopathies - Phase 5 (BS5) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

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