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Award details
PrPc expression and function on cells of the immune system in scrapie susceptible and resistant sheep
Reference
BS516338
Principal Investigator / Supervisor
Professor Ian McConnell
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Veterinary Medicine
Funding type
Research
Value (£)
413,392
Status
Completed
Type
Research Grant
Start date
01/01/2002
End date
30/06/2005
Duration
42 months
Abstract
In this proposal we present evidence that sheep which are genetically susceptible or resistant to scrapie differ in the expression of particular epitopes of PrPc on the surface of lymphocytes. This difference may be associated with development and differentiation of PrPc+ lymphocyte subsets in vivo and be important in the peripheral pathogenesis of scrapie in the lymphoreticular system. This project will analyse expression of PrPc and allele specific PrPc epitopes on lymphocyte subsets isolated from different lymphoid compartments of the immune system in sheep and determine whether lymphocyte PrPc has a role in lymphocyte activation.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Biology of Spongiform Encephalopathies - Phase 5 (BS5) [2001]
Funding Scheme
X – not Funded via a specific Funding Scheme
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