Award details

Oral TSE pathogenesis: identification of neuroanatomical pathways and interaction with lymphoid tissue

Reference	BS410572
Principal Investigator / Supervisor	Mrs Patricia McBride
Co-Investigators / Co-Supervisors	Dr Moira Bruce
Institution	The Pirbright Institute
Department	Neuropathogenesis Unit
Funding type	Research
Value (£)	184,044
Status	Completed
Type	Research Grant
Start date	01/04/1999
End date	12/09/2002
Duration	41 months

Abstract

The oral route of infection is the most relevant pathway for natural transmission of TSEs within different species. However, the mechanisms involved are poorly understood and a better understanding is vital to intervention and prevention. The lymphoreticular and peripheral nervous systems are involved in the uptake of infection. The spleen harbours infectivity soon after infection and this is subsequently targeted to sites in the CNS via the PNS but the interaction between the two systems is unknown. This project aims to use a mouse model of scrapie to identify the neuroanatomical pathways and timing of events involved in spread of infection from the gut through the LRS and peripheral NS to the CNS. We also plan to orally-infect mouse models in which either the immune or sympathetic nervous systems are functionally deficient in order to separate the individual roles in spread of infection.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Biology of Spongiform Encephalopathies - Phase 4 (BS4) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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