BBSRC Portfolio Analyser
Award details
PrPsc glycoform analysis and the origins of natural TSE strains in sheep
Reference
BS410563
Principal Investigator / Supervisor
Professor Nora Hunter
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
Neuropathogenesis Unit
Funding type
Research
Value (£)
120,305
Status
Completed
Type
Research Grant
Start date
20/04/1999
End date
20/04/2002
Duration
36 months
Abstract
PrPSc, the TSE associated isoform of PrPC a neuronal glycoprotein, shows molecular heterogeneity due to differential glycosylation and partial proteolysis which have been said to be TSE strain dependent. The particular patterns and apparent molecular weights of bands produced by PrPSc on Western blots following treatment with proteinase K are called glycoforms and have shown some consistency in association with different TSE sources, for example BSE and nvCJD. This proposal seeks to take advantage of the large scale project already funded by BBSRC to study epidemiology of natural scrapie in 100 flocks throughout the UK by carrying out PrPSc glycoform analysis of scrapie affected animals from these flocks. This study will test the hypothesis that PrPSc glycoforms are useful in revealing the origins of different strains of natural TSEs.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Biology of Spongiform Encephalopathies - Phase 4 (BS4) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search