Award details

Scrapie strain influences on the cellular targeting of infection in the peripheral lymphoid system

Reference	BS410559
Principal Investigator / Supervisor	Dr Moira Bruce
Co-Investigators / Co-Supervisors	Dr MARTIN JEFFREY
Institution	The Pirbright Institute
Department	Neuropathogenesis Unit
Funding type	Research
Value (£)	284,179
Status	Completed
Type	Research Grant
Start date	17/08/1999
End date	17/08/2002
Duration	36 months

Abstract

Our recent studies of the ME7 mouse scrapie strain indicate that follicular dendritic cells (FDCs) of the spleen produce PrP, support replication and are critical for neuroinvasion. In contrast, studies elsewhere have implicated B cells in replication and neuroinvasion after challenge of mice with the RML scrapie isolate. We will test the hypothesis that different scrapie strains target different cell types of the immune system. Knockout mice lacking specific cells of the immune system will be challenged with different scrapie strains, to determine their susceptibility and whether infectivity can replicate in their spleens. We will also determine the cellular and subcellular location of PrP within the spleen for a range of scrapie strains.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Biology of Spongiform Encephalopathies - Phase 4 (BS4) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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