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Investigation of scrapie pathogenesis in the lymphoreticular system using in vivo germinal centre cultivation as a model system
Reference
BS410558
Principal Investigator / Supervisor
Dr Moira Bruce
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
Neuropathogenesis Unit
Funding type
Research
Value (£)
212,274
Status
Completed
Type
Research Grant
Start date
05/01/2000
End date
05/01/2003
Duration
36 months
Abstract
Recent data from our laboratory and elsewhere suggests that different mouse passaged strains of scrapie may use different cells within the LRS to process and/or replicate infectivity. In the programme outlined below, we intend to use the in vitro cultivation of germinal centre cells as a model in which to study (I) the expression of PrP by various cell populations within the germinal centre, (II) which cell populations are important for replication of a variety of scrapie strains, (III) the effect of immune activation on susceptibility to infection with scrapie, (IV) the induction of either scrapie-specific immune responses to scrapie-induced alterations to normal function and (V) the role of PrP in normal immune function.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Biology of Spongiform Encephalopathies - Phase 4 (BS4) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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