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The role of calcium and voltage- and calcium-gated potassium channels in TSE-related apoptotic cell death
Reference
BS410554
Principal Investigator / Supervisor
Dr Nikki Macleod
Co-Investigators /
Co-Supervisors
Professor Alun Williams
Institution
University of Edinburgh
Department
Biomedical Sciences
Funding type
Research
Value (£)
233,014
Status
Completed
Type
Research Grant
Start date
01/05/1999
End date
01/05/2002
Duration
36 months
Abstract
We have recently demonstrated a link between increased excitability and the disruption of voltage-gated and calcium-gated potassium channel function in hippocampal neurones from ME7 scrapie-infected mice. It seems likely from this observation that impaired potassium channel function maybe the trigger for the cascade of events leading to elevated intracellular calcium and apoptotic cell death in these diseases. This hypothesis will be tested in detail using a combination of voltage clamp, cellular imaging, electron and confocal microscopy in hippocampal neurones from scrapie infected mice and by the application of PrP fragments and apoptosis inducing agents to acute preparations of non-infected cells in culture and in brain slices.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Biology of Spongiform Encephalopathies - Phase 4 (BS4) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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