Award details

Prion protein function and neurodegeneration in a prion disease model

Reference	BS410551
Principal Investigator / Supervisor	Professor Alastair Compston
Co-Investigators / Co-Supervisors	Professor David Brown
Institution	University of Cambridge
Department	Cambridge Centre for Brain Repair
Funding type	Research
Value (£)	144,699
Status	Completed
Type	Research Grant
Start date	15/02/1999
End date	15/02/2002
Duration	36 months

Abstract

The aim of this project is to investigate the mechanism of neurotoxicity of a prion protein peptide in cell culture. Four aspects will be investigated: (i) direct toxicity of the prion protein peptide (ii) cellular uptake of prion protein peptide (iii) changes in copper metabolism induced by the peptide (iv) the role and function of prion protein expression in different types, and if loss of this function is induced by the peptide. The function of the prion protein has been suggested to be related to some aspect of copper metabolism and this shall be further investigated. This project should indicate loss of prion protein function is important to neuronal death in prion disease models and in which cell types this loss of function is important. A completed model of the mechanism of action of PrP106-126 involving route of uptake and binding partners will be developed.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Biology of Spongiform Encephalopathies - Phase 4 (BS4) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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