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The relationship between neuron damage and clinical disease: relating murine and ovine scrapie to BSE and CJD
Reference
BS410537
Principal Investigator / Supervisor
Dr Janet Fraser
Co-Investigators /
Co-Supervisors
Professor James Ironside
,
Dr MARTIN JEFFREY
Institution
The Pirbright Institute
Department
Neuropathogenesis Unit
Funding type
Research
Value (£)
155,962
Status
Completed
Type
Research Grant
Start date
01/06/1999
End date
01/06/2002
Duration
36 months
Abstract
The pathology of the TSEs is immensely varied and yet shows considerable congruity between species; however, the pathophysiological basis for clinical disease is not known. This study will combine three areas of pathological research: experimental studies on murine scrapie, scrapie in sheep and BSE in cattle, and CJD in man. Evidence from murine scrapie suggests that neuronal dysfunction initiated at the synapse underlines clinical disease. We propose to test this observation in sheep scrapie, BSE, and CJD by quantifying neuron morphology using confocal imaging and morphometric techniques and correlating with synaptic degeneration. A reliable method of estimating synapse number and integrity will be developed and applied to murine, ovine, bovine and human CNS.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Biology of Spongiform Encephalopathies - Phase 4 (BS4) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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