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Propagation of the PrP transition in cultured neural cells

Reference	BS308131
Principal Investigator / Supervisor	Professor Jeremy Brockes
Co-Investigators / Co-Supervisors	Professor Christopher Bostock
Institution	University College London
Department	Structural Molecular Biology
Funding type	Research
Value (£)	260,462
Status	Completed
Type	Research Grant
Start date	01/10/1997
End date	31/01/2001
Duration	40 months

Abstract

The aim of the present proposal is to investigate how the transition between the cellular and scrapie forms of the prion protein propagates between neural cells and within neurones. The approach proposed is to confront identified populations in dissociated cell culture such that the relative importance of diffusible signals and cell contact can be evaluated, as well as any dependence on particular neuronal or glial cell types. Dissociated sensory neurons will be cultured under conditions that permit detection of the transition in the soma or axon terminals, and analysis of any subsequent anterograde or retrograde propagation. This work should have general implications for our understanding of pathogenesis in the SEs, as well as providing possible test systems for agents which might inhibit propagation.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Biology of Spongiform Encephalopathies - Phase 3 (BS3) [1996-1997]
Funding Scheme	X – not Funded via a specific Funding Scheme

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