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In vitro investigation of neuron-PrP-glia interactions in the pathogenesis of scrapie
Reference
BS204822
Principal Investigator / Supervisor
Professor Alun Williams
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
Neuropathogenesis Unit
Funding type
Research
Value (£)
118,046
Status
Completed
Type
Research Grant
Start date
01/07/1995
End date
01/07/1998
Duration
36 months
Abstract
Scrapie infection in the CNS results in the accumulation of pathologically-modified forms of PrP, neuronal death and marked microglial and astrocytic responses. However, the precise interactions between infected neurons, PrP metabolism and activated glia are unclear. We propose that glia become activated on exposure to pathologically-altered forms of PrP and that the neuronal survival/death in scrapie is mediated via the effects of activated glia. To test this, the effects of different PrP preparations on astrocytes and microglia in vitro will be examined. The effects that the glial conditioned media obtained have on cultured neurons will then be studied. Individual components of the conditioned medium will be tested for specific effects on neuron survival/death.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Biology of Spongiform Encephalopathies - Phase 2 (BS2) [1993]
Funding Scheme
X – not Funded via a specific Funding Scheme
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