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Neuronal pathology in CJD: an immunocytochemical study with quantitative macroscopic and microscopic analysis

Reference	BS204814
Principal Investigator / Supervisor	Professor James Ironside
Co-Investigators / Co-Supervisors	Professor Jeanne Bell, Professor Robert Will
Institution	University of Edinburgh
Department	Pathology
Funding type	Research
Value (£)	164,342
Status	Completed
Type	Research Grant
Start date	01/08/1995
End date	01/05/2000
Duration	57 months

Abstract

A study of neuronal pathology in CJD is proposed employing novel automated microscopic techniques for quantification of cellular populations and 3-dimensional reconstruction in relation to macroscopic MRI brain images. The findings will be compared to other neuronal abnormalities as revealed by immunocytochemistry and confocal laser microscopy (with specific reference to microglial interactions) and to clinical features in sporadic, familial and iatrogenic CJD cases. The results will provide new information on the pathogenic mechanisms and patterns of neuronal loss in the 3 main subgroups of CJD, allow a fuller understanding of the potential influence of the BSE agent on man.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Biology of Spongiform Encephalopathies - Phase 2 (BS2) [1993]
Funding Scheme	X – not Funded via a specific Funding Scheme

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