Award details

Study of sheep PrP gene variants in transgenic mice

Reference	BS204791
Principal Investigator / Supervisor	Professor Nora Hunter
Co-Investigators / Co-Supervisors	Dr Wilfred Goldmann
Institution	The Pirbright Institute
Department	Neuropathogenesis Unit
Funding type	Research
Value (£)	264,719
Status	Completed
Type	Research Grant
Start date	02/10/1995
End date	02/10/1999
Duration	48 months

Abstract

Incidence of scrapie is associated with dimorphisms of the sheep PrP gene at codons 136 and 171. In experimental scrapie, there is evidence that either codon 136 or codon 171 is dominant in control of different scrapie sources. With natural scrapie this is less clear. To improve our understanding of the interaction of the PrP protein with scrapie and the species barrier, transgenic mice will be made using homologous recombination with different sheep PrP gene variants. These mice and their heterozygote crosses will be challenged with two sources of scrapie. The effect on gene expression by exchanging the mouse promoter sequence for that of sheep will also be examined.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Biology of Spongiform Encephalopathies - Phase 2 (BS2) [1993]
Funding Scheme	X – not Funded via a specific Funding Scheme

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