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An investigation of scrapie pathogenesis in the spleen using immunodeficient transgenic and chimaeric mouse models
Reference
BS204514
Principal Investigator / Supervisor
Dr Moira Bruce
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
Neuropathogenesis Unit
Funding type
Research
Value (£)
399,073
Status
Completed
Type
Research Grant
Start date
01/04/1995
End date
31/08/1999
Duration
53 months
Abstract
In natural and experimental scrapie, the major sites of agent replication outside the CNS are the spleen and lymph nodes. The objective is to test the hypothesis that replication in the spleen occurs predominantly in mature follicular dendritic cells (FDCs). This will be achieved by the manipulation and infection of immunodeficient and PrP null mice. Immunodeficient mice will be reconstituted by grafting bone marrow from appropriate donors to produce chimaeric mice which (a) express PrP in FDCs but not in lymphoid and/or myeloid cells and (b) express PrP in lymphoid and/or myeloid cells but not in FDCs. These mice will be used to address a series of questions concerning the role of FDCs and other cell types in scrapie pathogenesis.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Biology of Spongiform Encephalopathies - Phase 2 (BS2) [1993]
Funding Scheme
X – not Funded via a specific Funding Scheme
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