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Award details
Scrapie strain-typing and PrP analysis in cell culture
Reference
BS204513
Principal Investigator / Supervisor
Dr Christopher Birkett
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
Div of Molecular Biology
Funding type
Research
Value (£)
202,951
Status
Completed
Type
Research Grant
Start date
01/04/1995
End date
01/04/1999
Duration
48 months
Abstract
PrP-Sc production in the persistently scrapie-infected cell line SMB is sensitive to scrapie- prophylactic compounds. Such compounds are useful tools for accessing the site of PrP-C to PrP-Sc transformation. Having stopped PrP-Sc production in a sub-line of SMB, it has been possible to re-infect only with selected scrapie strains. Determination of whether the scrapie strain-specific determinants persist in culture is of importance in determining the nature of the transmissible agent.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Biology of Spongiform Encephalopathies - Phase 2 (BS2) [1993]
Funding Scheme
X – not Funded via a specific Funding Scheme
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