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Peptide and antibody delivery to the rhizosphere: the need for and disruption of root exudate sensing by nematodes
Reference
BRE13636
Principal Investigator / Supervisor
Prof. Howard Atkinson
Co-Investigators /
Co-Supervisors
Dr Catherine Lilley
,
Professor Peter Urwin
Institution
University of Leeds
Department
Plant Biochemistry & Biotechnology
Funding type
Research
Value (£)
215,764
Status
Completed
Type
Research Grant
Start date
26/03/2001
End date
26/03/2004
Duration
36 months
Abstract
The promoters and signal sequence of constructs will be optimised for the delivery of bioactive peptides and antibodies from roots to the rhizosphere. A previously defined peptide known to disrupt chemoreception of nematodes at low concentration and an antibody with similar activity will be studied as exemplars of the approach. The rhizosphere concentration required to disrupt nematode invasion of roots will be determined. The minimal persistence consistent with efficacy will be defined and stability enhanced. The potential of the peptide and the antibody will be compared. The work will determine if chemoreception of exudates by nematodes is essential for root invasion and if it can be disrupted in the rhizosphere.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Biological Interactions in the Root Environment (BRE) [2000]
Funding Scheme
X – not Funded via a specific Funding Scheme
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